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Lal, Roshan
- Safety Evaluation of Arsenicum Album in Acute and Sub-Acute Toxicity Studies in Rats
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Authors
Roshan Lal
1,
Mahima sharma
1,
Sangita Behera
1,
Raj Kumar Regar
1,
Deepika Tripathi
1,
G V Narasimha Kumar
2,
Satvinder Singh
1,
Digvijay Verma
3,
Pankaj Gupta
1,
Subhash Kaushik
3,
Anil Khurana
3
Affiliations
1 Department of Pharmacology, Dr. D. P. Rastogi, Central Council for Research in Homoeopathy, Noida - 201301, Uttar Pradesh, IN
2 Dr Anjali Chatterji Regional Research Institute for Homoeopathy, Kolkata - 700035, West Bengal, IN
3 Central Council for Research in Homoeopathy, New Delhi - 110023, IN
1 Department of Pharmacology, Dr. D. P. Rastogi, Central Council for Research in Homoeopathy, Noida - 201301, Uttar Pradesh, IN
2 Dr Anjali Chatterji Regional Research Institute for Homoeopathy, Kolkata - 700035, West Bengal, IN
3 Central Council for Research in Homoeopathy, New Delhi - 110023, IN
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 30, No 2 (2023), Pagination: 233-247Abstract
Arsenic album is frequently prescribed in homoeopathy for many diseases. However, its safety data is not available. Thus, the study’s purpose is to evaluate the oral toxicity of Arsenic album 6C, 30C, and 200C in rats. Arsenic album (6C, 30C, and 200C) was given at 2000 μl/kg for acute toxicity and observed for up to 14 days. For subacute toxicity, it was given for 28 days and observed for clinical signs, change in body weight and Mortality. Hematological, biochemical, organ weight and histopathological analyses were assessed. Results indicate no mortality of arsenic album in acute toxicity and LD50 is >2000 μl/kg. In the subacute toxicity study, arsenic album (200 μl/kg) did not show any significant changes in above parameters. It may be concluded that the arsenic album (6C, 30C, and 200C) is safe and produces no toxicity when administered orally for a prolonged duration at 200 μl/kg in rats.Keywords
Complementary and Alternative Medicines, Homoeopathy, Safety, Toxicity.
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